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Multiple side effects often occur when a patient starts taking Gabapentin. Gabapentin prevents epileptic fits by preventing the excessive electrical activity in the brain in balance. Gabapentin helps keep the nerve activity in the brain in balance. Topical pain relievers are also available without a doctor's prescription. Depending on the type of joint pain you have, there are other medications that your doctor may suggest in addition to, pain medications. What is the most important information I should know about Gabapentin? More powerful prescription pain reliever. Gabapentin helps keep the nerve activity in the brain. The burning nerve pain that sometimes persists for months.