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Metformin can rarely cause a serious condition called lactic acidosis. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal or as directed by your doctor. Metformin can rarely cause a serious condition called lactic acidosis. Metformin delays absorption of sugar from the blood hence in type 2 diabetes. Glucophage tablets contain the active ingredient Metformin hydrochloride. Diabetes medication Metformin is being prescribed to increase glucose sensitivity and promote weight loss process. Metformin is used as a first line treatment of type 2 diabetes. Insulin, which promotes the burning of sugar. Metformin can rarely cause a serious condition called lactic acidosis.