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Esomeprazole works best if taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Use this medication. Esomeprazole capsules should be taken at least one hour before meals and at the same time every day. Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium. What should my health care professional know before I take Esomeprazole? Nexium is usually taken once a day at least one hour before a meal. What should you watch for while taking Esomeprazole? Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection.

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